Antineoplastic medical product CISPLACEL

We developed a novel antineoplastic medical product «Cisplacel». Active substance of the product is cis-dichlorodimethylsilane (II) (cisplatin), which is immobilized on the cellulose (IV), oxidized with nitrogen oxide. The product is haemostatic and has a prolonged citostatic action can dissolve when implanted into organism in 20-30 days. It is designed for local chemotherapy of brain malignant growth including growths in head and neck area by implantation into the bed of the eliminated tumor. The use of «Cisplacel» facilitates prolongation of brain glioma patients’(Grade III-IV) life expectancy in more than 2 times. In case of combined treatment of neck and head growths the use of «Cisplacel» gives complete recovery for 51% of patients and the reduction of relapses makes 25-40%. We suggested a concrete innovation solution by creating original medical product on the basis of the developed technology.

The synthesis scheme of pharmaceutical substance "Cisplatin" has been developed in RUE "Unidragmet BSU" together with the Institute of Physical and Chemical Problems of Belarusian State University. The substance and the active agent of the known drug "Cisplatin" have been proved to be identical