Technology of production of hepatoprotective flavolignans such as silibinin, silydianin and silychristine from Silybum

Purpose

Production of medical drugs based on Silybum marianum fruits. The technology allows to obtain individual flavolignans oil and oilseed meal from Silybum marianum fruits for the production of hepatoprotective flavolignans: silibinin silydianin and silychristin

Characteristics

The technology involves several stages:
• grinding of raw materials
• oil extraction
• extract separation via column low-pressure chromatography
• evaporation, filtration, drying of separate flavolignans fractions
• oilseed meal drying

Advantages

• versatility of the technology
• production of individual flavolignans of specified composition
• possibility to use inexpensive organic solvents
• available production equipment
• production of high-purity preparations of silibinin, silidianin and silychristin in isocratic elution conditions at one chromatography stage

Silybum marianum is an acknowledged source of raw material used for production of hepatoprotective drugs

Application

Pharmaceutical and food industries